59.6 Folate:Active B12
59.6.1 Global tests
Type III ANOVA on main and interaction effects, and LM model summaries.
Prolactin| Chisq | Df | Pr(>Chisq) | ||
|---|---|---|---|---|
| (Intercept) | 105.9654174 | 1 | <0.0001 | *** |
| folate_Active.B12 | 2.8507424 | 1 | 0.09 | ns |
| GDM_new | 1.1655961 | 1 | 0.3 | ns |
| Study | 6.9823448 | 1 | 0.008 | ** |
| GA_samp | 66.5831228 | 1 | <0.0001 | *** |
| folate_Active.B12:GDM_new | 0.0040185 | 1 | 0.9 | ns |
| GDM_new:Study | 0.9576216 | 1 | 0.3 | ns |
| folate_Active.B12:Study | 7.2599035 | 1 | 0.007 | ** |
| folate_Active.B12:GDM_new:Study | 0.0013920 | 1 | 1.0 | ns |
| Chisq | Df | Pr(>Chisq) | ||
|---|---|---|---|---|
| (Intercept) | 13.9681088 | 1 | 0.0002 | *** |
| folate_Active.B12 | 0.4096199 | 1 | 0.5 | ns |
| GDM_new | 0.0935974 | 1 | 0.8 | ns |
| Study | 14.4440520 | 1 | 0.0001 | *** |
| GA_samp | 1058.4296326 | 1 | <0.0001 | *** |
| folate_Active.B12:GDM_new | 2.3157121 | 1 | 0.1 | ns |
| GDM_new:Study | 0.2657622 | 1 | 0.6 | ns |
| folate_Active.B12:Study | 5.2239565 | 1 | 0.02 | * |
| folate_Active.B12:GDM_new:Study | 4.8125063 | 1 | 0.03 | * |
| Chisq | Df | Pr(>Chisq) | ||
|---|---|---|---|---|
| (Intercept) | 190.2290308 | 1 | <0.0001 | *** |
| folate_Active.B12 | 1.0860066 | 1 | 0.3 | ns |
| GDM_new | 0.1049198 | 1 | 0.7 | ns |
| Study | 1.3273208 | 1 | 0.2 | ns |
| GA_samp | 492.6053979 | 1 | <0.0001 | *** |
| folate_Active.B12:GDM_new | 1.2525421 | 1 | 0.3 | ns |
| GDM_new:Study | 0.1156740 | 1 | 0.7 | ns |
| folate_Active.B12:Study | 1.9208434 | 1 | 0.2 | ns |
| folate_Active.B12:GDM_new:Study | 0.8227386 | 1 | 0.4 | ns |
| model term | df1 | df2 | F.ratio | Chisq | p.value | ||
|---|---|---|---|---|---|---|---|
| 1 | folate_Active.B12 | 1 | Inf | 4.471 | 4.471 | 0.03 | * |
| 5 | GDM_new | 1 | Inf | 27.005 | 27.005 | <0.0001 | *** |
| 7 | Study | 1 | Inf | 9.213 | 9.213 | 0.002 | ** |
| 8 | GA_samp | 1 | Inf | 0.005 | 0.005 | 0.9 | ns |
| 2 | folate_Active.B12:GDM_new | 1 | Inf | 0.518 | 0.518 | 0.5 | ns |
| 4 | folate_Active.B12:Study | 1 | Inf | 0.028 | 0.028 | 0.9 | ns |
| 6 | GDM_new:Study | 1 | Inf | 0.836 | 0.836 | 0.4 | ns |
| 3 | folate_Active.B12:GDM_new:Study | 1 | Inf | 1.318 | 1.318 | 0.3 | ns |
| model term | df1 | df2 | F.ratio | Chisq | p.value | ||
|---|---|---|---|---|---|---|---|
| 1 | folate_Active.B12 | 1 | Inf | 5.750 | 5.750 | 0.02 | * |
| 5 | GDM_new | 1 | Inf | 24.286 | 24.286 | <0.0001 | *** |
| 7 | Study | 1 | Inf | 13.077 | 13.077 | 0.0003 | *** |
| 8 | GA_samp | 1 | Inf | 0.143 | 0.143 | 0.7 | ns |
| 2 | folate_Active.B12:GDM_new | 1 | Inf | 0.855 | 0.855 | 0.4 | ns |
| 4 | folate_Active.B12:Study | 1 | Inf | 0.001 | 0.001 | 1.0 | ns |
| 6 | GDM_new:Study | 1 | Inf | 0.717 | 0.717 | 0.4 | ns |
| 3 | folate_Active.B12:GDM_new:Study | 1 | Inf | 1.532 | 1.532 | 0.2 | ns |
| model term | df1 | df2 | F.ratio | Chisq | p.value | ||
|---|---|---|---|---|---|---|---|
| 1 | folate_Active.B12 | 1 | Inf | 4.993 | 4.993 | 0.03 | * |
| 5 | GDM_new | 1 | Inf | 3.118 | 3.118 | 0.08 | ns |
| 7 | Study | 1 | Inf | 23.055 | 23.055 | <0.0001 | *** |
| 8 | GA_samp | 1 | Inf | 1.291 | 1.291 | 0.3 | ns |
| 2 | folate_Active.B12:GDM_new | 1 | Inf | 1.879 | 1.879 | 0.2 | ns |
| 4 | folate_Active.B12:Study | 1 | Inf | 0.387 | 0.387 | 0.5 | ns |
| 6 | GDM_new:Study | 1 | Inf | 1.832 | 1.832 | 0.2 | ns |
| 3 | folate_Active.B12:GDM_new:Study | 1 | Inf | 0.193 | 0.193 | 0.7 | ns |
59.6.2 Model summary
Ratio of Geometric means (95% CI)
Prolactin| Var | Effect | P |
|---|---|---|
| (Intercept) | 2.88 (2.33, 3.42) | <0.0001 |
| folate_Active.B12 | -0.00 (-0.00, 0.00) | 0.08 |
| GDM_newGDM | -0.22 (-0.54, 0.10) | 0.17 |
| StudySTOP | -0.29 (-0.50, -0.08) | 0.007 |
| GA_samp | 0.14 (0.11, 0.17) | <0.0001 |
| folate_Active.B12:GDM_newGDM | -0.00 (-0.00, 0.00) | 0.95 |
| GDM_newGDM:StudySTOP | 0.23 (-0.09, 0.54) | 0.16 |
| folate_Active.B12:StudySTOP | 0.00 (0.00, 0.00) | 0.004 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 0.55 (0.26, 0.83) | 0.0002 |
| folate_Active.B12 | 0.00 (-0.00, 0.00) | 0.52 |
| GDM_newGDM | -0.03 (-0.24, 0.17) | 0.76 |
| StudySTOP | 0.22 (0.11, 0.33) | 0.0002 |
| GA_samp | 0.30 (0.28, 0.31) | <0.0001 |
| folate_Active.B12:GDM_newGDM | -0.00 (-0.00, 0.00) | 0.13 |
| GDM_newGDM:StudySTOP | -0.06 (-0.29, 0.17) | 0.61 |
| folate_Active.B12:StudySTOP | -0.00 (-0.00, -0.00) | 0.02 |
| folate_Active.B12:GDM_newGDM:StudySTOP | 0.00 (0.00, 0.00) | 0.03 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | -2.63 (-3.00, -2.26) | <0.0001 |
| folate_Active.B12 | -0.00 (-0.00, 0.00) | 0.19 |
| GDM_newGDM | -0.12 (-0.34, 0.10) | 0.27 |
| StudySTOP | -0.10 (-0.24, 0.04) | 0.18 |
| GA_samp | 0.27 (0.24, 0.29) | <0.0001 |
| folate_Active.B12:GDM_newGDM | -0.00 (-0.00, 0.00) | 0.50 |
| GDM_newGDM:StudySTOP | 0.15 (-0.07, 0.37) | 0.17 |
| folate_Active.B12:StudySTOP | 0.00 (-0.00, 0.00) | 0.07 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 2.76 (2.09, 3.44) | <0.0001 |
| folate_Active.B12 | -0.00 (-0.00, 0.00) | 0.09 |
| GDM_newGDM | 1.06 (0.59, 1.53) | <0.0001 |
| StudySTOP | -0.37 (-0.63, -0.10) | 0.006 |
| GA_samp | -0.00 (-0.04, 0.04) | 0.96 |
| folate_Active.B12:GDM_newGDM | -0.00 (-0.00, 0.00) | 0.38 |
| GDM_newGDM:StudySTOP | -0.44 (-0.90, 0.02) | 0.06 |
| folate_Active.B12:StudySTOP | 0.00 (-0.00, 0.00) | 0.39 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 1.46 (0.73, 2.18) | <0.0001 |
| folate_Active.B12 | -0.00 (-0.00, 0.00) | 0.08 |
| GDM_newGDM | 1.15 (0.61, 1.69) | <0.0001 |
| StudySTOP | -0.53 (-0.81, -0.25) | 0.0002 |
| GA_samp | -0.01 (-0.05, 0.04) | 0.72 |
| folate_Active.B12:GDM_newGDM | -0.00 (-0.00, 0.00) | 0.28 |
| GDM_newGDM:StudySTOP | -0.48 (-1.00, 0.05) | 0.07 |
| folate_Active.B12:StudySTOP | 0.00 (-0.00, 0.00) | 0.43 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 1.81 (1.65, 1.97) | <0.0001 |
| folate_Active.B12 | -0.00 (-0.00, -0.00) | 0.0006 |
| GDM_newGDM | 0.16 (-0.03, 0.34) | 0.09 |
| StudySTOP | -0.16 (-0.21, -0.11) | <0.0001 |
| GA_samp | -0.01 (-0.02, 0.00) | 0.25 |
| folate_Active.B12:GDM_newGDM | -0.00 (-0.00, 0.00) | 0.11 |
| GDM_newGDM:StudySTOP | -0.13 (-0.31, 0.05) | 0.17 |
| folate_Active.B12:StudySTOP | 0.00 (-0.00, 0.00) | 0.47 |
59.6.3 Estimated means
Estimated marginal means (or adjusted means) adjusted for GA at sampling.
Results are averaged over the levels of Folate:Active B12 ratio and may be misleading when interaction term is involved.
| Study | GDM_new | response | SE | df | lower.CL | upper.CL |
|---|---|---|---|---|---|---|
| SCOPE | Uncomplicated | 101.62816 | 9.314017 | 132.5548 | 84.77824 | 121.8271 |
| STOP | Uncomplicated | 90.29880 | 7.578499 | 94.9709 | 76.44011 | 106.6701 |
| SCOPE | GDM | 81.05772 | 13.016128 | 534.6951 | 59.12887 | 111.1192 |
| STOP | GDM | 90.21198 | 9.467076 | 203.8058 | 73.35054 | 110.9494 |
| Study | GDM_new | response | SE | df | lower.CL | upper.CL |
|---|---|---|---|---|---|---|
| SCOPE | Uncomplicated | 88.04922 | 3.026850 | 288.7021 | 82.28881 | 94.21288 |
| STOP | Uncomplicated | 101.59394 | 2.988394 | 163.6881 | 95.86127 | 107.66944 |
| SCOPE | GDM | 75.32856 | 5.693745 | 550.9688 | 64.93511 | 87.38558 |
| STOP | GDM | 100.33245 | 4.462084 | 371.6288 | 91.93106 | 109.50163 |
| Study | GDM_new | response | SE | df | lower.CL | upper.CL |
|---|---|---|---|---|---|---|
| SCOPE | Uncomplicated | 2.293818 | 0.0966457 | 343.5562 | 2.111390 | 2.492009 |
| STOP | Uncomplicated | 2.235757 | 0.0771283 | 204.6502 | 2.088745 | 2.393116 |
| SCOPE | GDM | 1.958147 | 0.1944361 | 557.8906 | 1.611167 | 2.379852 |
| STOP | GDM | 2.228177 | 0.1214521 | 354.5442 | 2.001677 | 2.480307 |
| Study | GDM_new | response | SE | df | asymp.LCL | asymp.UCL |
|---|---|---|---|---|---|---|
| SCOPE | Uncomplicated | 14.52969 | 1.1290796 | Inf | 12.47702 | 16.92006 |
| STOP | Uncomplicated | 10.62686 | 0.6103258 | Inf | 9.49551 | 11.89300 |
| SCOPE | GDM | 39.13558 | 7.9435717 | Inf | 26.29048 | 58.25658 |
| STOP | GDM | 18.48524 | 1.9016206 | Inf | 15.10984 | 22.61467 |
| Study | GDM_new | response | SE | df | asymp.LCL | asymp.UCL |
|---|---|---|---|---|---|---|
| SCOPE | Uncomplicated | 3.552503 | 0.2995868 | Inf | 3.011283 | 4.190996 |
| STOP | Uncomplicated | 2.206362 | 0.1346450 | Inf | 1.957634 | 2.486692 |
| SCOPE | GDM | 10.223246 | 2.4037386 | Inf | 6.448374 | 16.207925 |
| STOP | GDM | 3.937619 | 0.4329703 | Inf | 3.174226 | 4.884607 |
| Study | GDM_new | response | SE | df | asymp.LCL | asymp.UCL |
|---|---|---|---|---|---|---|
| SCOPE | Uncomplicated | 5.541282 | 0.0858373 | Inf | 5.375572 | 5.712100 |
| STOP | Uncomplicated | 4.764642 | 0.0648083 | Inf | 4.639298 | 4.893372 |
| SCOPE | GDM | 6.267473 | 0.5260221 | Inf | 5.316822 | 7.388102 |
| STOP | GDM | 4.746362 | 0.0798218 | Inf | 4.592464 | 4.905416 |
59.6.4 Comparisons
59.6.4.1 Within Groups
Effect for every 500 unit increase in Folate:Active B12 ratio.| Hormone | Contrast | Study | GDM_new | Ratio of Geometric means (95% CI) | P-value |
|---|---|---|---|---|---|
| Prolactin | folate_Active.B121123.57 / folate_Active.B12623.57 | SCOPE | Uncomplicated | 0.958 (0.913, 1.005) | 0.08 |
| Prolactin | folate_Active.B121123.57 / folate_Active.B12623.57 | STOP | Uncomplicated | 1.057 (1.006, 1.110) | 0.03 |
| Prolactin | folate_Active.B121123.57 / folate_Active.B12623.57 | SCOPE | GDM | 0.955 (0.874, 1.045) | 0.3 |
| Prolactin | folate_Active.B121123.57 / folate_Active.B12623.57 | STOP | GDM | 1.054 (0.980, 1.133) | 0.2 |
| HPL | folate_Active.B121123.57 / folate_Active.B12623.57 | SCOPE | Uncomplicated | 1.009 (0.983, 1.035) | 0.5 |
| HPL | folate_Active.B121123.57 / folate_Active.B12623.57 | STOP | Uncomplicated | 0.965 (0.939, 0.992) | 0.01 |
| HPL | folate_Active.B121123.57 / folate_Active.B12623.57 | SCOPE | GDM | 0.939 (0.860, 1.026) | 0.2 |
| HPL | folate_Active.B121123.57 / folate_Active.B12623.57 | STOP | GDM | 1.010 (0.967, 1.056) | 0.6 |
| GH2 | folate_Active.B121123.57 / folate_Active.B12623.57 | SCOPE | Uncomplicated | 0.978 (0.947, 1.011) | 0.2 |
| GH2 | folate_Active.B121123.57 / folate_Active.B12623.57 | STOP | Uncomplicated | 1.021 (0.986, 1.057) | 0.2 |
| GH2 | folate_Active.B121123.57 / folate_Active.B12623.57 | SCOPE | GDM | 0.958 (0.899, 1.022) | 0.2 |
| GH2 | folate_Active.B121123.57 / folate_Active.B12623.57 | STOP | GDM | 1.000 (0.949, 1.055) | 1.0 |
| Insulin | folate_Active.B121123.57 / folate_Active.B12623.57 | SCOPE | Uncomplicated | 0.958 (0.912, 1.007) | 0.09 |
| Insulin | folate_Active.B121123.57 / folate_Active.B12623.57 | STOP | Uncomplicated | 0.989 (0.934, 1.047) | 0.7 |
| Insulin | folate_Active.B121123.57 / folate_Active.B12623.57 | SCOPE | GDM | 0.922 (0.847, 1.005) | 0.06 |
| Insulin | folate_Active.B121123.57 / folate_Active.B12623.57 | STOP | GDM | 0.952 (0.879, 1.031) | 0.2 |
| HOMA.IR | folate_Active.B121123.57 / folate_Active.B12623.57 | SCOPE | Uncomplicated | 0.955 (0.907, 1.006) | 0.08 |
| HOMA.IR | folate_Active.B121123.57 / folate_Active.B12623.57 | STOP | Uncomplicated | 0.985 (0.926, 1.048) | 0.6 |
| HOMA.IR | folate_Active.B121123.57 / folate_Active.B12623.57 | SCOPE | GDM | 0.908 (0.826, 0.998) | 0.05 |
| HOMA.IR | folate_Active.B121123.57 / folate_Active.B12623.57 | STOP | GDM | 0.936 (0.861, 1.018) | 0.1 |
| GLUC3_mmol.L | folate_Active.B121123.57 / folate_Active.B12623.57 | SCOPE | Uncomplicated | 0.991 (0.986, 0.996) | 0.0006 |
| GLUC3_mmol.L | folate_Active.B121123.57 / folate_Active.B12623.57 | STOP | Uncomplicated | 0.996 (0.984, 1.008) | 0.5 |
| GLUC3_mmol.L | folate_Active.B121123.57 / folate_Active.B12623.57 | SCOPE | GDM | 0.971 (0.945, 0.998) | 0.04 |
| GLUC3_mmol.L | folate_Active.B121123.57 / folate_Active.B12623.57 | STOP | GDM | 0.976 (0.957, 0.995) | 0.02 |
59.6.4.2 Between Groups
Below are comparisons of the differences in the change in Folate:Active B12 ratio between groups. I.e. whether the change in Folate:Active B12 ratio are different between groups.
| contrast | ratio | SE | df | lower.CL | upper.CL | p.value | |
|---|---|---|---|---|---|---|---|
| SCOPE/SCOPE (Overall) | 1.2168295 | 0.0822859 | 683.0468 | 1.065532 | 1.389610 | 0.004 | ** |
| STOP/SCOPE (Uncomplicated) | 1.1030999 | 0.0372976 | 683.0468 | 1.032246 | 1.178817 | 0.004 | ** |
| STOP/SCOPE (GDM) | 1.1030999 | 0.0372976 | 683.0468 | 1.032246 | 1.178817 | 0.004 | ** |
| GDM/Uncomplicated (SCOPE) | 0.9973718 | 0.0422328 | 642.2031 | 0.917795 | 1.083848 | 0.950 | ns |
| GDM/Uncomplicated (STOP) | 0.9973718 | 0.0422328 | 642.2031 | 0.917795 | 1.083848 | 0.950 | ns |
| contrast | ratio | SE | df | lower.CL | upper.CL | p.value | |
|---|---|---|---|---|---|---|---|
| SCOPE/SCOPE (Overall) | 1.0293092 | 0.0555449 | 422.6078 | 0.9257213 | 1.1444885 | 0.593 | ns |
| STOP/SCOPE (Uncomplicated) | 0.9569665 | 0.0184170 | 709.0099 | 0.9214827 | 0.9938168 | 0.023 | * |
| STOP/SCOPE (GDM) | 1.0755958 | 0.0538283 | 407.0315 | 0.9748181 | 1.1867919 | 0.146 | ns |
| GDM/Uncomplicated (SCOPE) | 0.9313548 | 0.0435245 | 362.4851 | 0.8495777 | 1.0210034 | 0.129 | ns |
| GDM/Uncomplicated (STOP) | 1.0468090 | 0.0276512 | 716.9310 | 0.9939056 | 1.1025284 | 0.084 | ns |
| contrast | ratio | SE | df | lower.CL | upper.CL | p.value | |
|---|---|---|---|---|---|---|---|
| SCOPE/SCOPE (Overall) | 1.0891701 | 0.0517284 | 662.4498 | 0.9921909 | 1.195628 | 0.073 | ns |
| STOP/SCOPE (Uncomplicated) | 1.0436331 | 0.0247828 | 662.4498 | 0.9960878 | 1.093448 | 0.073 | ns |
| STOP/SCOPE (GDM) | 1.0436331 | 0.0247828 | 662.4498 | 0.9960878 | 1.093448 | 0.073 | ns |
| GDM/Uncomplicated (SCOPE) | 0.9796986 | 0.0299631 | 662.5828 | 0.9225964 | 1.040335 | 0.503 | ns |
| GDM/Uncomplicated (STOP) | 0.9796986 | 0.0299631 | 662.5828 | 0.9225964 | 1.040335 | 0.503 | ns |
| contrast | ratio | SE | df | asymp.LCL | asymp.UCL | p.value | |
|---|---|---|---|---|---|---|---|
| SCOPE/SCOPE (Overall) | 1.0649411 | 0.0772902 | Inf | 0.9237363 | 1.227731 | 0.386 | ns |
| STOP/SCOPE (Uncomplicated) | 1.0319598 | 0.0374482 | Inf | 0.9611120 | 1.108030 | 0.386 | ns |
| STOP/SCOPE (GDM) | 1.0319598 | 0.0374482 | Inf | 0.9611120 | 1.108030 | 0.386 | ns |
| GDM/Uncomplicated (SCOPE) | 0.9623745 | 0.0419947 | Inf | 0.8834879 | 1.048305 | 0.379 | ns |
| GDM/Uncomplicated (STOP) | 0.9623745 | 0.0419947 | Inf | 0.8834879 | 1.048305 | 0.379 | ns |
| contrast | ratio | SE | df | asymp.LCL | asymp.UCL | p.value | |
|---|---|---|---|---|---|---|---|
| SCOPE/SCOPE (Overall) | 1.0631318 | 0.0826268 | Inf | 0.9129177 | 1.238063 | 0.431 | ns |
| STOP/SCOPE (Uncomplicated) | 1.0310828 | 0.0400680 | Inf | 0.9554673 | 1.112683 | 0.431 | ns |
| STOP/SCOPE (GDM) | 1.0310828 | 0.0400680 | Inf | 0.9554673 | 1.112683 | 0.431 | ns |
| GDM/Uncomplicated (SCOPE) | 0.9506305 | 0.0447923 | Inf | 0.8667710 | 1.042603 | 0.283 | ns |
| GDM/Uncomplicated (STOP) | 0.9506305 | 0.0447923 | Inf | 0.8667710 | 1.042603 | 0.283 | ns |
| contrast | ratio | SE | df | asymp.LCL | asymp.UCL | p.value | |
|---|---|---|---|---|---|---|---|
| SCOPE/SCOPE (Overall) | 1.0099613 | 0.0139150 | Inf | 0.9830534 | 1.037606 | 0.472 | ns |
| STOP/SCOPE (Uncomplicated) | 1.0049683 | 0.0069231 | Inf | 0.9914905 | 1.018629 | 0.472 | ns |
| STOP/SCOPE (GDM) | 1.0049683 | 0.0069231 | Inf | 0.9914905 | 1.018629 | 0.472 | ns |
| GDM/Uncomplicated (SCOPE) | 0.9798727 | 0.0125141 | Inf | 0.9556499 | 1.004709 | 0.111 | ns |
| GDM/Uncomplicated (STOP) | 0.9798727 | 0.0125141 | Inf | 0.9556499 | 1.004709 | 0.111 | ns |